Presentation description

This project seeks further our understanding of the role of Reg expression in the neonatal pancreas. Using a Reg3 KO mouse model, we can determine whether the presence of Regs is necessary for neonatal beta-cell proliferation, and whether it is dependent upon microbial signals. The presence of Enterococcus, Candida dubliniensis, and Escherichia in mice have been shown to rescue beta-cell mass in mice. My project explores whether individual microbes promote beta-cells through Reg3 expression.