Presentation description

Fecal microbial transplant (FMT) has shown promise as an effective therapeutic intervention for Clostridioides difficile infection (CDI), a leading cause of healthcare-associated diarrhea in the United States. FMT enables patients to acquire a gut microbiota diversity like that of healthy donors, contributing to successful clinical outcomes. However, the impact of intestinal-targeted interventions, such as FMT, on off-target (other) tissues remains poorly understood. Therefore, exploring the changes induced by FMT in off-site tissues such as the oral microbiome can provide valuable insights into the broader effects of this treatment on patient microbiomes. In this study, we utilized shotgun metagenomics data from 9 CDI patients and 6 healthy controls to investigate longitudinal alterations in the oral microbiome at various stages before and after FMT treatment. This study will contribute to the current knowledge by shedding light on the longitudinal dynamics of the oral microbiome in response to FMT treatment. Ultimately, this knowledge may aid in examining the potential of FMT for treatment of non-intestinal diseases.