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Regulation of Protein Complexes During Hedgehog Signal Transduction

Semester: Fall 2021

Presentation description

I used bioluminescence resonance energy transfer (BRET) to investigate interactions between different proteins in the Hedgehog (Hh) pathway. I focused on Kif7 and SuFu interactions with the GPCR Smoothened (SMO) and PKA-C. Kif7 is analogous to Cos2 in fruit flies. Cos2 scaffolds the GLI transcription factor and PKA-C. I suspect that Kif7 may play a similar role. Kif7 and SuFu may also play a role in PKA-C binding to SMO.

Presenter Name: William Steiner
Presentation Type: Poster
Presentation Format: Virtual
Presentation #16
College: Medicine
School / Department: Oncological Sciences
Research Mentor: Ben Myers


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