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Procoagulant Platelet Formation and Function: Mitochondrial Calcium Uniporter’s Role in Platelet Activation

Semester: Spring 2024

Presentation description

This study explores the role of mitochondrial calcium uniporters (MCU) in platelet activation and its implications for thrombosis. Murine experiments reveal MCU deficiency alters platelet activation pathways, affecting aggregation, mitochondrial calcium flux, and reactive oxygen species (ROS) generation. Findings suggest the MCU plays a crucial role in mediating platelet activation and thrombosis in an ITAM-dependent manner. Targeting the MCU may offer a strategy for reducing thrombotic events.

Presenter Name: Mia Kowalczyk

Presentation Type: Poster
Presentation Format: In Person
Presentation #A36
College: Medicine
School / Department: Internal Medicine
Research Mentor: Robert Campbell
Date | Time: Tuesday, Apr 9th | 9:00 AM