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Murine Model of Hepatitis Delta-Associated Salivary Gland Impairment

Semester: Summer 2023


Presentation description

In a 2016 study, Hepatitis Delta Virus (HDV) sequence and antigens were detected in the minor salivary gland acinar, ductal, and adipose cells of patients diagnosed with Sjogren's Disease (SjD) without the presence of a Hepatitis B Virus coinfection. In this study, the effects of HDV on the SjD phenotype were evaluated by inducing expression of the virus in murine models. This evaluation was accomplished through analysis of focal inflammation in the salivary glands, saliva flow, autoantibodies, and RNA-sequencing data. Findings included significant increases in inflammation for glands expressing the Short HDV antigen, and significant increase of anti-SSA antibodies for models expressing the Short HDV antigen

Presenter Name: Alexander Romano

Presentation Type: Poster
Presentation Format: In Person
Presentation #39
College: Dentistry
School / Department: Dentistry
Research Mentor: Melodie Weller
Date | Time: Thursday, Aug 3rd | 9:00 AM