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In a 2016 study, Hepatitis Delta Virus (HDV) sequence and antigens were detected in the minor salivary gland acinar, ductal, and adipose cells of patients diagnosed with Sjogren's Disease (SjD) without the presence of a Hepatitis B Virus coinfection. In this study, the effects of HDV on the SjD phenotype were evaluated by inducing expression of the virus in murine models. This evaluation was accomplished through analysis of focal inflammation in the salivary glands, saliva flow, autoantibodies, and RNA-sequencing data. Findings included significant increases in inflammation for glands expressing the Short HDV antigen, and significant increase of anti-SSA antibodies for models expressing the Short HDV antigen