Choroid plexus carcinoma is a rare malignant brain tumor in children. Currently, the treatment of choroid plexus carcinoma involves surgical removal followed by irradiation and chemotherapy. Irradiation and chemotherapy can lead to devastating toxic side effects on the normal brain tissue of children. Immune checkpoint inhibitors such as anti-CD47 antibodies showed promise in the treatment of different malignant brain tumors in our preclinical studies. We propose to use different combinations of anti-CD47 and other immune checkpoint inhibitors to enhance the phagocytosis of human choroid plexus carcinoma.