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Lactate Dehydrogenase Regulation by Adenosine Triphosphate (ATP)

Semester: Fall 2023


Presentation description

Lactate dehydrogenase (LDH) catalyzes the reversible conversion of lactate to pyruvate with the concurrent reduction of NAD+ to NADH which is essential in metabolism. LDHA is highly expressed in the liver and LDHB is the predominant isoform in the heart. Knowing that ATP inhibits LDHA, not LDHB. This regulation reduces lactate production and increases glucose production via pyruvate-fueled gluconeogenesis, highlighting the liver's crucial role in glucose homeostasis.

Presenter Name: Andy Lee

Presentation Type: Poster
Presentation Format: Virtual
Presentation #29
College: Medicine
School / Department: Biochemistry
Research Mentor: Aaron Leifer

Video