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Investigating conopeptides targeting voltage-gated potassium channels

Semester: Spring 2024

Presentation description

This work is focused on the effects of conotoxins on homomeric Kv1.2 channels, and how beta subunits impact the biophysical properties of KV1.2. Mu3.1, a conotoxin isolated from Conus mucronatus, was tested on isolated Xenopus oocytes (expressing human Kv1.2). Using a two-electrode voltage clamp technique, we observed that Mu3.1 blocks the outward K-currents from homomeric Kv1.2 channels. To study K-channels, we use conotoxins (neuroactive peptides isolated from the venom of marine cone snails).

Group Member: Shannon Anderson

Presenter Name: Merrin Maughan

Presentation Type: Poster
Presentation Format: In Person
Presentation #A14
College: Science
School / Department: Biological Sciences
Research Mentor: Shrinivasan Raghuraman
Date | Time: Tuesday, Apr 9th | 9:00 AM