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Intracellular Amino Acid Accumulation in Cell Lines Cultured in Amino Acid Deficient Growth Media

Semester: Fall 2022

Presentation description

A frequent adaptation in the development of melanoma is the downregulation of arginionsuccinate synthetase 1 (ASS1). Examining the effects of arginine deprivation on ASS1 deficient cells, we found that in low arginine media these cells displayed a phenotype characterized by intracellular amino acid accumulation when compared to cells grown in arginine replete media. Understanding the pathways by which these cells respond to amino acid deficiencies could reveal novel cancer treatment options.

Presenter Name: Austin Bender
Presentation Type: Poster
Presentation Format: Virtual
Presentation #27
College: Medicine
Research Mentor: Gregory Ducker
Physical Location or Zoom link:

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