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Inhibiting CDK9 and Autophagy in Pancreatic Cancer

Semester: Spring 2024


Presentation description

The majority of PDAC cases arise from mutations in KRAS, a GTPase involved in the MAP Kinase (MAPK) pathway. Inhibition of the MAPK pathway upregulates autophagy, a process in which cells recycle their intracellular components to sustain nutrient demands under stressful conditions and can render targeted therapies ineffective. . We are searching for drugs that are FDA-approved or in clinical trials and modulate autophagy for potential repurposing in novel combinations.

Presenter Name: Isabella Scalise

Presentation Type: Poster
Presentation Format: In Person
Presentation #C33
College: Medicine
School / Department: Oncological Sciences
Research Mentor: Conan Kinsey
Date | Time: Tuesday, Apr 9th | 1:00 PM