Presentation description

Co-abuse of methamphetamine (METH) and the opioid, fentanyl (FEN), is a major public health problem. Prior data indicate that individuals that abuse METH are more likely to develop Parkinson's Disease, particularly individuals with a history of opioid exposure. Thus, we posited that if METH and FEN are co-administered, a METH-induced dopaminergic deficit would occur. Results revealed concurrent exposure did not exacerbate METH-induced dopaminergic deficits as assessed ex vivo in treated rats.