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Ceramides & Metabolic Dysfunction; Exploring a New Molecular Culprit

Semester: Spring 2024


Presentation description

Type 2 diabetes is distinguished by insulin resistance. partial insulinopenia, & lipotoxicity, which yields way to high blood sugar and excess fat accumulation. As a consequence, several lipid metabolites including sphingolipids are increased and most importantly, long-chain ceramides, which are causal agents for insulin resistance and steatosis. A diversity outbred panel of mice were screened to find transcripts that were quantitative trait loci for type 2 diabetes. It is suspected that lipid-metabolizing genes could be related to ceramide metabolism or lipid accumulation in the cells. A subset of these genes were overexpressed in an in-vitro model to discern which ones influenced ceramide levels, and to further characterize this relatively unknown subset.

Presenter Name: Amaya Pfannenstiel

Presentation Type: Poster
Presentation Format: In Person
Presentation #B37
College: Health
School / Department: Nutrition & Integrative Physiology
Research Mentor: Scott Summers
Date | Time: Tuesday, Apr 9th | 10:45 AM