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Full Synthesis of Enzymatically Cleavable Linker Between 929-Designed Ankyrin Repeat Protein And 17-Dimethlyamino Geldanamycin

Semester: Fall 2021


Presentation description

An enzymatically cleavable linker was synthesized to conjugate 17-Dimethylamino Geldanamycin (DMAG) and 929 designed ankyrin repeat protein (929-DARPin) where DMAG was used to inhibit the route of endosomal recycling, and 929-DARPin used as the ligand to bind to HER-2. We will be able to co-dose 929DARPin-DMAG and TDM-1 in order to see the changes in efficacy of TDM-1 as well as explore other linker applications to overcome drug resistance.

Presenter Name: Eshan Narasipura

Presentation Type: Poster
Presentation Format: Virtual
Presentation #19
College: Pharmacy
School / Department: Pharmaceutics & Pharmaceutical Chemistry
Research Mentor: Shawn Owen

Audio