Presentation description

An enzymatically cleavable linker was synthesized to conjugate 17-Dimethylamino Geldanamycin (DMAG) and 929 designed ankyrin repeat protein (929-DARPin) where DMAG was used to inhibit the route of endosomal recycling, and 929-DARPin used as the ligand to bind to HER-2. We will be able to co-dose 929DARPin-DMAG and TDM-1 in order to see the changes in efficacy of TDM-1 as well as explore other linker applications to overcome drug resistance.