Presentation description

Buildup of fat cells, such as ceramides, lead to lipotoxicity which play a role in a number of diseases pertinent in society such as Type 2 diabetes, heart and kidney failure, and obesity to name a few. Ceramides are a stronger predictor of diabetes than measuring blood glucose levels, and can predict whether an individual will have diabetes in the future. In this discovery-based project, the aim is to assess the effects of a couple newly identified drivers of ceramide accumulation, IL-33 & APOH, and how the over-expression thereof effects ceramide levels, as well as its implications and significance in disease.