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Exploring G-quadruplex binding by the C-terminal Zinc Fingers of the Methyl-CpG Binding Protein ZBTB4 Gabriela M. Eyring, Brandon Leonel Guerra Castañaza Jenkins, Bethany A. Buck

Semester: Spring 2024


Presentation description

ZBTB4 is part of a methyl-CpG binding protein family involved in regulating normal and disease relevant transcription. While the N-terminal zinc fingers (ZFs) are known to provide methyl-specific DNA readout, the role of the C-terminal ZF domain was undefined. We discovered this domain recognizes G-quadruplex DNA. A combination of solution NMR and electrophoretic mobility shift assays have been used to characterize this binding; which expands understanding of ZBTB4 transcriptional activities.

Presenter Name: Gabriela Eyring

Presentation Type: Poster
Presentation Format: In Person
Presentation #C22
College: Science
School / Department: Chemistry
Research Mentor: Bethany Buck-Koehntop
Date | Time: Tuesday, Apr 9th | 1:00 PM