Systemic side effects from medication can be reduced by using targeted drug delivery. Targeted drug delivery can be achieved by delivering the medication in a nanoparticle shell. The goal of this project was to effectively encapsulate and release neuromodulatory drug ketamine from a specific type of nanoparticles in-vitro using ultrasound. Results showed that release is higher when nanoparticles are radiated with ultrasound. Further improvements to the experiment were proposed.