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Effect of DSTAT on the Drug CPX-351

Semester: Summer 2023


Presentation description

Acute Myeloid Leukemia (AML) is a deadly blood cancer, with a 5-year survival rate of 30.5% and 11,540 deaths every year. AML tends to hide in bone marrow during chemotherapy, causing cancer cells to lie dormant for years, reawakening in a patient with an immunity to chemotherapy. Our purpose for this experiment was to evaluate the synergistic effect of DSTAT to Vyxeos. We used the HL-60 AML cell line and observed its reaction with Vyxeos and DSTAT . We used different concentrations of DSTAT and Vyxeos in two sets of five 96 well plates. DSTAT appeared to have caused a synergistic effect, increasing the cytotoxic effect of Vyxeos but there could be other reasons for why we are seeing it in our data. It appears that Vyxeos may not be stable when DSTAT is added. Vyxeos also becomes unstable overtime after checking at 7 and 14 days post mixing. We need to determine if DSTAT is causing the liposome to leak out Vyxeos to rule out synergy.|

Presenter Name: Kiran Echavarria

Presentation Type: Poster
Presentation Format: In Person
Presentation #69
College: Medicine
School / Department: Biochemistry
Research Mentor: Paul Shami
Date | Time: Thursday, Aug 3rd | 10:30 AM