Presentation description

Cyclophane motifs present in natural products, pharmaceuticals, and asymmetric ligands (e.g., Phanephos), are structurally intriguing and important, yet can be challenging to prepare. Recently, the Roberts group developed a strategy to build polycyclic (hetero)aromatics from simple to prepare tertiary amines. The tertiary amine templates are processed into polycyclic (hetero)aromatics using developed reductive cyclization and deaminative contraction methods.