Presentation description

This project examined the phenotypes resulting from altered BWA expression in Drosophila to develop a cancer treatment screen based upon phenotypic comparison. BWA is an alkaline ceramidase in Drosophila that converts ceramide to sphingosine-1-phosphate (S1P). Increased amounts of S1P have been linked to tumor formation, indicating that BWA over-expression may contribute to tumorigenesis. As such, a method to determine BWA-inhibiting treatments is desired.