Laboratory research opportunity studying CRISPR editing and platelets

Faculty Mentor: Jesse Rowley

Title: Research Associate Professor

College: Medicine

School / Department: Internal Medicine

Project description

The Rowley Lab (www.plateletlab.com) is seeking exceptional students to join their team within the platelet group at the University of Utah. Platelets are cells that stick to holes in blood vessels to stop bleeding. They also contribute to clot formation for example in heart attacks or strokes. Students will research how genetics and mitochondria influence platelet function, bleeding, and clot formation. In one project, students will participate in projects utilizing cutting-edge CRISPR/Cas9 approaches in human blood cells to evaluate gene functions and the effect of genetic variants in blood cells, including platelets and megakaryocytes. In another project, students will assess how mitochondria affect platelet function using mouse knockout models.

Keywords: CRISPR platelets genetics cell biology blood

Student Role: Student roles will highly depend on prior experience and interests, ability to perform laboratory calculations (be prepared for a quiz on dilution problems :) and ability to learn techniques. Possible tasks include microscopy, blood cell isolation, PCR, mouse handling, CRISPR transfections into cells, flow cytometry, western blots.

Project Duration: 8-20 hours per week. 1-3 years.

Opportunity Type: Research Assistant

Opportunity Location Type: In Person

Is this a paid opportunity: ToBeDetermined

Paid Description:

Volunteer, This is a paid research position, This is a work-study research position, Prepare a UROP proposal, Write an Honors Thesis or Senior Thesis.

Minimum Requirements: Must be able to perform standard laboratory calculations (dilution problems). Previous lab experience preferred but not required. CV or resume required.

How To Apply: Contact Jesse Rowley jesse.rowley@u2m2.utah.edu