Presentation description

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by clonal expansion of myeloid blasts in the bone marrow(BM). Despite advances in therapy, the prognosis for AML patients remains poor, and there is a need to identify novel molecular pathways regulating tumor cell survival and proliferation. FBXO32 is the 2nd highly expressed FBOX protein in MOLM-13 cells, showing that it has a may have a more active role in AML than other FBXOs.Knockout of FBXO32 in malignant hematopoietic cell lines led to a decreased rate of apoptosis, showing that FBXO32 may have a role in the growth of hematopoietic malignancies. These findings reveal the ubiquitin E3 ligase, FBXO32 may have a function of tumor suppression in AML lines.