Presentation description

Cancer develops when DNA damage goes unrepaired and mutations accumulate. Nup50 and its binding partners, Nup153 and RCC1, are all individually required for 53BP1 to initiate repair at DNA damage sites. I tested mutant versions of Nup50 that are deficient in binding either Nup153 or RCC1 to determine whether those interactions play a role in 53BP1 regulation.