Presentation description

Rab26 is a neuron-specific GTPase in Drosophila melanogaster known to play a role in synaptic autophagy, and it has also been implicated in additional cellular processes in mammalian liver and pancreatic cells. The function of its closest ortholog in the nematode Caenorhabditis elegans, RAB-37b, remains uncharacterized. This project aims to investigate the localization and function of RAB-37b by utilizing fluorescent protein tagging and fluorescence microscopy to determine where RAB-37b is predominantly localized in neurons, which proteins it colocalizes with, and how RAB-37b mutants affect neuronal structure and function.