Presentation description

Our research explores histone lactylation, a novel post-translational modification linking metabolism to chromatin regulation. We identified specific "reader" proteins that bind lactylated histones, suggesting Kla acts as a signaling mark to influence gene expression. This reveals how metabolic shifts, like glycolysis, impact epigenetics, with implications for tissue repair, immune response, and cancer. These findings provide new insights into disease mechanisms and potential therapeutic target.