Presentation description

Breast cancer remains one of the most prevalent cancers in women. Studies suggest that lipid metabolism and nutrient availability play critical roles in the survival and proliferation of cancer cells. Free fatty acids (FFA) are essential for cell function but become toxic at high concentrations, a phenomenon termed lipotoxicity. The length and saturation of FFAs is thought to influence the type of cell death induced. Saturated fatty acids (SFA) encourage apoptosis, polyunsaturated fatty acids (PUFA) encourage ferroptosis, and monounsaturated fatty acids (MUFA) have been shown to inhibit both forms of cell death. This study evaluates how different FFAs affect the survival and proliferation of E0771 murine breast cancer cells. We test the hypothesis that SFA and PUFA exhibit dose dependent toxicity, while MUFA exert a protective effect. By establishing the LD50 of palmitate, a saturated fatty acid, and comparing growth outcomes across treatments, this study aims to determine how fatty acid composition influences cancer cell viability and inform future tumor targeting strategies.
Funding for CE was provided by American Heart Association 25IAUST1374429