Presentation description

X-linked Adrenoleukodystrophy (ALD) is a rare disease caused by mutations in the ABCD1 gene, leading to very long-chain fatty acid accumulation. ALD mechanisms remain unclear, however, our ALD fibroblasts show disrupted lysosomal-peroxisomal contacts. Since lysosomal cholesterol accumulation can arrest oligodendrocyte development, we are testing whether Telmisartan, which relieves this accumulation, can rescue oligodendrocyte deficiencies in ALD zebrafish, offering potential therapeutic insight.