Presentation description

During ischemia the peptide GJA1-20k: increases gene expression, centralizes to the mitochondrial membrane, and decreases oxygen consumption. The multifactorial protective effect of GJA1-20k is critical to the survival of tissues experiencing ischemia. This study investigates GJA1-20k as a potential therapeutic drug in a pig model of ischemia reperfusion injury. It was found that with intravenous GJA1-20k treatment during ischemia the renal cortex had increased ATP concentrations.