Presentation description

Protein carbonylation, resulting from oxidative stress, disrupts cellular functions by modifying proteins, lipids, and DNA. These modifications can impair protein function, alter signaling pathways, and promote cellular dysfunction. Protein carbonyls are implicated in various diseases, including neurodegenerative disorders like Alzheimer's and Parkinson's, cardiovascular diseases, diabetes, and age-related muscle loss. The purpose of this study is to develop a high-throughput proteomic method for assessing these proteins. Understanding the nature of protein carbonyls in these conditions is crucial for developing targeted therapies to mitigate its harmful effects and improve the quality of life in affected individuals.