Presentation description

Previous research suggests AAV and other parvoviruses are released by cell lysis. However, we, and others, found that AAV particles are released from cells in the absence of cell death. This discrepancy implies a distinct, non-lytic cellular pathway facilitating AAV egress. To elucidate this process, we investigated the intracellular trafficking of assembled adeno-associated virus type 2 (AAV-2) capsids. By determining the subcellular localizations of anterograde AAV-2 capsids, we aim to identify potential cellular machinery involved in their exit from the cell.