Presentation description

This project computationally investigates how voltage changes across potassium channels and the W434F mutation in the Shaker Kv channel impacts ion conduction. Simulations are performed for wild-type Shaker under various ion concentrations, ion occupancies, and applied voltages to identify a protocol for quantifying the voltage drop. Comparison with the mutant indicates how voltage profiles adjust to changes in the selectivity filter, shedding light on W434F induced rapid c-type inactivation.