Poster 119: Rachel Cantrell – Towards the Synthesis of an Antibiotic Scaffold Inspired by the TAN 1057-D Biologically Active Natural Product

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Faculty mentor: Ryan Looper

The TAN 1057 family of compounds show promising biological activity. This project involves the synthesis of a TAN 1057-D inspired heterocyclic core. A modular synthetic strategy has been implemented to construct the heterocyclic core of TAN 1057-D. The core has been synthesized through the utilization of Ullmann copper(I) chemistry, and core manipulation is in progress to allow for analog development. Synthesis of analogs will inform the structural characteristics of a future drug candidate.

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Questions or comments? Contact me at: rachellcantrell@yahoo.com

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