Poster 65: Lauren Thompson – Inducible Disruption of Endothelial Cell Ceramide Biosynthesis: Vascular Implications

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Faculty mentor: J. David Symons

We tested the hypothesis that deleting ceramide biosynthesis specifically in endothelial cells (ECs) attenuates obesity-induced arterial dysfunction. Metabolic and vascular phenotyping was completed using wild type mice and mice with EC-specific deletion of Sptlc2 that consumed standard or high fat chow for 14-weeks. Preliminary results indicate obesity-induced metabolic and vascular disruptions are not attenuated by EC-specific Sptlc2 deletion.

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Questions or comments? Contact me at: u0945466@utah.edu


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