Faculty mentor: Benjamin Spike
CRIPTO has been shown to exert its effects through binding to GRP78 (glucose-regulated protein 78. We hypothesize that glucose deprivation and other stressors coincide with an increased localization of GRP78 to the cell-surface in breast cancer cells and that a novel blockade protein ALK4L75A-Fc can inhibit the promotion of oncogenic events (including proliferation, EMT, and increased stem cell-like phenotypes) that occur as a functional consequence of a CRIPTO induced signaling cascade.
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