Faculty mentor: Junco Warren
Perm1 (PGC-1 and ERR regulator, muscle 1) is a striated muscle-specific regulator of metabolism. Despite the dominant expression of Perm1 in the heart, its role in the healthy and diseased hearts is unknown. Our newly generated Perm1 knockout mice developed heart failure, concurrent with downregulation of proteins involved in oxidative phosphorylation. Thus, our study suggests that Perm1 is a novel regulator of cardiac energetics and function.
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