Poster 135: Gabriela Rocha – Investigation the role of the Unfolded Protein Response in Quiescence

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Faculty mentor: Julie Hollien

Cells initiate the unfolded protein response (UPR) to maintain the balance between protein load and folding capacity. The UPR involves the activation of PERK, an ER transmembrane kinase, which phosphorylates the eukaryotic translation initiation factor 2a, leading to temporary attenuation of translation and a decreased load on the ER. In addition to its role in the UPR, we are interested in Perk’s role in the temporary and reversible exit from the cell cycle, known as quiescence.

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Questions or comments? Contact me at: u0930163@utah.edu

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