Faculty mentor: Robert Campbell
The development of ischemic stroke is contributed to by dysregulated platelets/platelet necrosis. During inflammatory conditions such as thrombosis, neutrophils are recruited to the site of injury and release DNA into the extracellular milieu called NETs. Using an experimental mouse model with techniques such as tMCAO and imaging via confocal microscopy, it was determined that in the presence of NIF, fewer platelets and neutrophils were found in the brain as compared to when NIF was not present.
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