Faculty mentor: Markus Babst
Regulation of cell membrane transport proteins in S. cerevisiae is mediated through endocytosis. It is hypothesized that Leucine is a metabolic mediator directly affecting the upregulation of General Amino Acid Permeases (GAP1) to the membrane under starvation conditions. GAP1 is involved in regulating the intracellular concentration of amino acids. If they accumulate to cytotoxic levels in the cell, mitochondrial degradation is triggered leading to cell death.
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