Poster 81: Adara DeNiro – Developing Antibodies for Determining Structures of Polycystic Kidney Disease Proteins

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Faculty mentor: Erhu Cao 

Two proteins in the kidneys, polycystin-1 and polycystin-2, interact in renal tubules and promote the normal development and function of the kidneys. However, the proteins’ actions are not well understood. Polycystin-1 and Polycystin-2 are encoded by the PKD1 gene and the PKD2 gene respectively. A mutation in either of these genes can lead to ADPKD and eventually renal failure. Currently, there is no cure for ADPKD due to setbacks regarding structural determination of the ADPKD proteins.

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Questions or comments? Contact me at: u1135722@utah.edu

 

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