Faculty mentor: Erhu Cao
Two proteins in the kidneys, polycystin-1 and polycystin-2, interact in renal tubules and promote the normal development and function of the kidneys. However, the proteins’ actions are not well understood. Polycystin-1 and Polycystin-2 are encoded by the PKD1 gene and the PKD2 gene respectively. A mutation in either of these genes can lead to ADPKD and eventually renal failure. Currently, there is no cure for ADPKD due to setbacks regarding structural determination of the ADPKD proteins.
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