Poster 82: Adam Dickson – Effects of Farnesyltransferase Inhibitors on Endothelial Cell Function in Cerebral Cavernous Malformations (CCM)

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Faculty mentor: Anthony Donato

Elucidating the effects of FTI Lonafarnib as a potential therapeutic treatment for CCM by increasing endothelial cell resistance and decreasing permeability to reduce capillary vessel “leakage.” We used a mouse model and immunocytochemistry, as well as, CT scan analysis and ECIS measuring to visualize the effects of Lonafarnib treated cells.

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Questions or comments? Contact me at: adamcdickson97@gmail.com

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