Poster 97: Aaron McMurray – Genetic Interactions and Osmoregulatory Effects of Human Disease Genes Blos4, Vps16B, Vps33B, and WNK in Drosophila

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Faculty mentor: Aylin Rodan

My research focus is the interaction of four Drosophila genes (Blos4, Vps16B, Vps33B, and WNK) and their effects on osmoregulation, using RNA interference, mutant crosses, and salt-sensitivity assays. These genes are implicated in membrane trafficking dysfunction and several human diseases. Results so far have shown that disruption of Blos4 or Vps33B suppresses the lethality of over-active WNK mutants and that knockdown of Vps16B causes a salt-sensitivity phenotype.

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Questions or comments? Contact me at: aarondavidmcmurray@gmail.com

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