Faculty mentor: Rajeshwary Ghosh
Protein degradation pathways are essential for maintaining protein homeostasis and thus normal cellular function. Chaperone Mediated Autophagy (CMA) is a novel protein degradation pathway that selectively degrades cytosolic and misfolded proteins containing a unique KFERQ-like motif. CRY-AB R120G has shown to accumulate in the heart and cause desmin-related cardiomyopathy. Our goal was to test if activating CMA can selectively deplete Cry-AB R120G before it accumulates and causes disease.
Watch my research presentation below.
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