SPUR 2021: Aeropollen exposure and the risk of suicide death in Utah

Background

Suicide is the 10th leading cause of death in the United States with the national economic costs of suicide approximated to be $53 billion annually. While suicide’s causes are complex, suicide clusters in families and it is widely hypothesized that interactions between an underlying genetic predisposition and environmental factors are in suicide’s causal pathway. We recently reported a heightened risk of suicide following short-term exposure to fine particulate matter and nitrogen dioxide among all suicides in Salt Lake County, Utah from 2000-2010. Similar findings have been replicated in culturally, meteorologically, and geographically diverse regions of the world including Japan, China, Korea, and Belgium. While the biological mechanisms underlying ambient air pollution exposure’s association with suicide have yet to be well-elucidated, growing evidence implicates a role for inflammation and oxidative stress. In addition to ambient air pollution, aeropollens (i.e. pollen grains located in the air) are another potential environmental exposure linked to suicide mortality that may elicit an inflammatory response to increase risk. If so, then both ambient air pollution and aeropollens represent modifiable risk factors for suicide mortality thereby providing opportunities for intervention. If so, it is important to understand comprehensively the association between aeropollens and suicide death. The relationship between aeropollens and suicide mortality, however, has yet to be investigated in a U.S. population.

This project is funded by a grant from the National Institute of Environmental Health Sciences (PIs: Sara Grineski and Tim Collins). In addition to being part of SPUR, it is also part of the HAPPIEST program. THIS MEANS THAT IT IS OPEN ONLY TO UNIVERSITY OF UTAH APPLICANTS FROM RACIAL/ETHNIC MINORITY BACKGROUNDS. Two students will be selected to work on this project together.

Student Role

The data elements required to conduct this project are currently available including suicide deaths from 2000-2019, measures of aeropollens from 2000-2019, ambient air pollutant concentrations from 2000-2019, and meteorological variables from 2000-2019. As this project is in the early stages, the student can expect to:

  1. conduct a literature review on the topic of aeropollens and suicidal behavior and mortality,
  2. assist with data preparation and management,
  3. assist with study design,
  4. conduct or assist with conducting descriptive analyses investigating changes in aeropollen levels and suicide death overtime in Utah, and
  5. conduct or assist with conducting a more complex case-crossover or time-series study to examine the relationship between aeropollen concentrations and risk of suicide mortality.

The student will also have the opportunity to participate in weekly lab meetings with other faculty, staff, and students.

Student Learning Outcomes & Benefits

At the conclusion of the summer program, the student will have completed a thorough literature review on the topic of aeroallergens and suicidal behavior and mortality, which will serve as the foundation of an introduction paper for a future journal article. The student will have gained a comprehensive understanding of what is known about aeropollens and suicide as well as current knowledge gaps. Further, the student will have gained experience with some statistical analysis approaches and with the interpretation of results. Most importantly, participation on this project will result in improvement in foundational skills for career development including writing and analytical skills.

Remote Contingency Plan

The proposed project will be conducted using existing data; no in-person contact is required. The student must have access to a computer and be willing to meet regularly over the Zoom.

Amanda Bakian
Research Associate Professor

Psychiatry
School of Medicine

My expertise in statistics and epidemiology puts me in a strong position to mentor undergraduate students in the design and analysis of individual- and ecologic-level studies assessing the relationship between ambient air pollution and risk of psychiatric outcomes. I can provide guidance throughout the experimental design process from hypothesis development and data acquisition/preparation to data analysis and interpretation. I have gained extensive mentoring experience participating on graduate student committees (4), mentoring Department of Psychiatry research staff (>10), and serving as the formal mentor to a junior faculty member. My hands-on approach encourages mentees to distill and articulate their interests and develop ideas and projects; at the same time, I will direct them to essential data and analytical resources. I strive to create a team environment inclusive of faculty, staff, and students, so that mentees benefit from input from senior researchers as well as peers.