**This project is a part of the Summer Program for Undergraduate Research (SPUR), which provides undergraduate students with an intensive 10-week research experience under the mentorship of a University of Utah faculty member. SPUR 2022 begins on May 25 and ends on August 4. If you are interested in this project, please review all program information on the SPUR site. If you wish to apply to this project, you must apply using the SPUR 2022 application.**
The research in Velayutham laboratory is focused on identifying the molecular mechanisms by which blueberry/strawberry-derived microbial metabolites improve endothelial dysfunction during metabolic syndrome (MetS). Human studies support the vascular beneficial effects of berry anthocyanins. Anthocyanins are extensively metabolized by the gut microbiota in humans, suggesting their vascular benefits might be mediated by their microbial metabolites. Velayutham lab showed that: blueberry/strawberry supplementation improves vascular inflammation and dysfunction, and increases the beneficial gut bacteria in diabetic mice; key blueberry metabolites attenuate palmitate-induced endothelial inflammation and vascular dysfunction (Mol Nutr Food Res 2018, Int J Cardiol 2018 & 2019, J Nutr Biochem 2019). Current research in Velayutham lab is focused on (1) determining the mechanisms by which anthocyanins-derived metabolites improve endothelial dysfunction in MetS, (2) determining the role of gut microbiota in mediating the vascular effects of blueberry/strawberry, and (3) determining the impact of circulating metabolites on endothelial dysfunction and identifying the most active metabolite(s). Physiologically relevant models and state of the art techniques will be used to evaluate the mechanistic roles of microbial metabolites of blueberries/strawberries at the cellular level, tissue level and organism level. This study will provide strong scientific rationale for recommending dietary intake of berries to improve vascular health in the US population and worldwide.
Analyzing Data: The student will assist in analyzing data and quantifying results using SPSS software (specifically t- test and ANOVA).
Developing additional skills in writing scientific abstracts/manuscripts, and presenting the research data at the lab meeting, seminars in other departments and at national scientific meetings such as Experimental Biology.