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Generation of a novel technology to degrade specific mutant proteins via lysosomes


Faculty Mentor: Rajeshwary Ghosh
Title: Research Assistant Professor
College: Health
School / Department: Nutrition & Integrative Physiology

Project description

Intracellular protein degradation pathways play an important role in maintaining protein homeostasis. Chaperone mediated autophagy (CMA) is a unique protein degradation pathway that employs chaperones for the selective delivery of substrate protein containing KFERQ-like motif to lysosomes for degradation. Our goal is to combine this unique feature of CMA, together with adeno-associated viral transgene delivery, to target specific mutant proteins for lysosomal degradation in heart cells.

Student Role: The student will be actively involved in the daily research activities of the lab, and in the process learn various biochemical and molecular biology techniques.
Project Duration: Project duration is for 1 year. Hours/week: 6 hours or more
Opportunity Type: Volunteer; Prepare a UROP proposal; Write an Honors Thesis or Senior Thesis; Earn independent study credit
Is this a paid opportunity: No
Minimum Requirements: None