Normal cells become cancerous as they acquire the ability to grow in a rogue manner and escape the body's natural defenses—a process that we still don't fully understand, which limits our ability to design more effective cancer therapies. We have two potential projects on this area for undergraduate researchers. In the first project, students can work with a team of PhD students to discover the mechanisms by which oncogenic (cancer-causing) kinases promote cancer cell proliferation and control inflammatory signaling. In the second project, students can discover how the cellular recycling process of autophagy regulates innate immune signaling to promote cancer growth. Both projects also involve the development of novel targeted cancer therapies.
Keywords: cell signaling, kinases, autophagy, molecular biology, biochemistry, cell biology
This is a paid research position