SPUR 2021: PERIPHERAL LIMITATIONS TO MAXIMAL OXYGEN UPTAKE IN PATIENTS WITH HEART FAILURE AND PRESERVED EJECTION FRACTION

Faculty Name:
Russell Richardson

Department:
Internal Medicine

Faculty College:
Medicine

Email:


Project Description:

**This project is a part of the Summer Program for Undergraduate Research (SPUR), which provides undergraduate students with an intensive 10-week research experience under the mentorship of a University of Utah faculty member. SPUR 2021 begins on May 26 and ends on August 5. If you are interested in this project, please review all program information on the SPUR site. If you wish to apply to this project, you must apply using the SPUR 2021 application.**

Heart failure with preserved ejection fraction (HFpEF) accounts for greater than 50% of all heart failure cases, and the prevalence relative to heart failure with reduced ejection fraction (HFrEF) continues to rise at a rate of 1% per year, with a 5-year survival rate as low as 50%. The pathophysiological differences between HFpEF and HFrEF, coupled with unsuccessful therapeutic strategies, highlight the need for improved understanding of HFpEF. The pathophysiological differences between HFpEF and heart failure with reduced ejection fraction (HFrEF), coupled with unsuccessful therapeutic strategies, highlight the need for improved understanding of HFpEF.

The defining symptom of HFpEF is marked exercise intolerance that greatly limits physical activity and quality of life. In patients with HFpEF, maximal oxygen uptake (VO2max), a primary determinant of prognosis and quality of life, has best quantified the severity of exercise intolerance. The peripheral limitations to VO2max will be determined in patients with HFpEF and controls by measuring leg maximal O2 delivery, O2 consumption, and mitochondrial oxidative capacity (Aim 1). Next, the identification of an O2-supply or O2-demand limitation will be validated by measuring the hyperoxia-induced changes in leg maximal O2 delivery and O2 consumption in patients with HFpEF and controls (Aim 2). Finally, the effect of knee-extensor training on the peripheral limitations to VO2max will be assessed by measuring the training-induced changes in leg maximal O2 delivery, O2 consumption, and mitochondrial oxidative capacity in patients with HFpEF and controls (Aim 3).

The stipend for this SPUR project is funded by an American Heart Association grant awarded to Dr. Stavros Drakos, MD, PhD. The stipend for this project is $4,000 instead of $5,000 due to grant funding limitations.



Opportunity Type:

This is a paid research position


Student Role:

The student will assist with patient visits to the laboratory, thus, getting first hand training in data collection and analysis. Specifically, the student will help calibrate devices and use the laboratory techniques for this study. This includes, but not limited to: Finapress, a non-invasive continuous blood pressure monitor; BioPak, data acquisition hardware; Single-leg ergometer; Blood gas analyzer. The student will observe leg catheter placements by our anesthesiologists, Doppler ultrasound testing of femoral blood flow and venous and arterial blood draws. The student will develop presentation skills by attending and presenting in the weekly UVRL Research in Progress and Journal Club meetings. Remote Contingency Plan: This project does not a have a remote contingency plan. While students from other institutions may apply for this project, preference may be given to University of Utah students and students local to the Salt Lake City area depending on travel and/or on-campus research restrictions at the time of award notifications.


Student Benefits:

Involvement in the proposed research project will provide the student with the required training to further develop their research capabilities in the field of applied clinical cardiovascular physiology and help their personal development toward becoming inquisitive and hypothesis driven scientists. The UVRL has had considerable success in assisting trainees to achieve their career goals and expect this to again be the case with the SPUR program.


Project Duration:

35-40 hours per week on research and program-related activities, begins May 26, 2021, and ends August 5, 2021


Minimum Requirements:

Admission to the program is competitive. Applicants must meet all of the following criteria: 1) be a matriculated, degree-seeking undergraduate student in the Fall 2021 semester (beginning or continuing college career in Fall 2021 and not graduating before December 2021; concurrent enrollment while in high school does not meet this eligibility requirement). Applicants do not need to be a University of Utah student. 2) eligible to work in the United States: If you are a University of Utah Dreamer (with or without DACA), you are eligible to participate. If you are a Dreamer from a different institution: If you have DACA, you are eligible to participate. If you do not have DACA, you are able to participate and gain research experience, but might not be able to be compensated. For more information, please contact Megan Shannahan at megan.shannahan@utah.edu or 801-581-2478. If you are an international student or scholar, you must either a) be a degree-seeking undergraduate student at an American institution of higher education and verify with your institution’s international center that your visa allows you to participate in this program, OR b) possess documentation that establishes your eligibility to work in the United States (if you hold US citizenship, it is likely you have these documents). 3) able to commit to approximately 35-40 hours per week of employment at the University of Utah for the entire duration of the program (May 26-August 5, 2021). 4) at least 18 years old by May 24, 2021 (required if you wish to use on-campus housing; preferred if you will not be using on-campus housing). Please note that no previous college coursework or previous research experience is required.