Role of Purinergic Signaling in Physiology and Pathophysiology

Faculty Name:
Bellamkonda Kishore

Department:
Internal Medicine (nephrology)

Faculty College:
Medicine

Email:
BK.Kishore@hsc.utah.edu


Project Description:

The focus of research is on the physiology, pathophysiology, and experimental therapeutics of purinergic signaling mediated by P2Y receptors in relation to renal diseases and obesity and insulin resistance. The approaches involve whole animal studies, molecular analysis of tissues, signaling mechanisms in isolated systems (ex vivo and cell cultures), mRNA and protein detection and quantification using rodent species, and transgenic mouse models. Several sub-projects on this theme are available for undergraduate students.



Opportunity Type:

Prepare a UROP proposal; Write an Honors Thesis; This is a paid research position


Student Role:

Performing isolation, detection and quantification of mRNA and protein, using RT-PCR, Western blotting, immunohistochemistry, and small animal experiments.


Student Benefits:

Gaining hands-on experience in modern techniques, co-authorship in abstracts and papers, and thus creation of strong foundation for higher studies.


Project Duration:

Project duration: 1-2 years or more. Approx. 15-20 hours/week.


Minimum Requirements:

Majoring in biology, physiology or pre-med. Although good GPA is needed, enthusiasm and motivation to learn and studious working habits are more important.