Mentor Name:
Rajeshwary Ghosh
Mentor Position:
Research Assistant Professor
Department:
Nutrition and Integrative Physiology
College:
Health
Email:
Rajeshwary.Ghosh@health.utah.edu
Project Description:
Intracellular protein degradation pathways play an important role in maintaining protein homeostasis. Chaperone mediated autophagy (CMA) is a unique protein degradation pathway that employs chaperones for the selective delivery of substrate protein containing KFERQ-like motif to lysosomes for degradation. Our goal is to combine this unique feature of CMA, together with adeno-associated viral transgene delivery, to target specific mutant proteins for lysosomal degradation in heart cells.
Opportunity Type:
Volunteer; Prepare a UROP proposal; Write an Honors Thesis or Senior Thesis; Earn independent study credit
Student Role:
The student will be actively involved in the daily research activities of the lab, and in the process learn various biochemical and molecular biology techniques.
Student Benefits:
This training will help them to facilitate their transition into a successful medical/healthcare professional.
Project Duration:
Project duration is for 1 year. Hours/week: 6 hours or more
Minimum Requirements:
None