Generation of a novel technology to degrade specific mutant proteins via lysosomes

Mentor Name:
Rajeshwary Ghosh

Mentor Position:
Research Assistant Professor

Nutrition and Integrative Physiology



Project Description:

Intracellular protein degradation pathways play an important role in maintaining protein homeostasis. Chaperone mediated autophagy (CMA) is a unique protein degradation pathway that employs chaperones for the selective delivery of substrate protein containing KFERQ-like motif to lysosomes for degradation. Our goal is to combine this unique feature of CMA, together with adeno-associated viral transgene delivery, to target specific mutant proteins for lysosomal degradation in heart cells.

Opportunity Type:

Volunteer; Prepare a UROP proposal; Write an Honors Thesis or Senior Thesis; Earn independent study credit

Student Role:

The student will be actively involved in the daily research activities of the lab, and in the process learn various biochemical and molecular biology techniques.

Student Benefits:

This training will help them to facilitate their transition into a successful medical/healthcare professional.

Project Duration:

Project duration is for 1 year. Hours/week: 6 hours or more

Minimum Requirements: