Effects of Docosahexaenoic Acid on Oxidative Stress White Matter Injury and Brain Inflammation in a Pre-Clinical Model of Pediatric Traumatic Brain Injury

Mentor Name:
Michelle Schober

Mentor Position:
Associate Professor

Department:
Pediatrics

College:
Medicine

Email:
michelle.schober@hsc.utah.edu


Project Description:

Hypothesis: docosahexaenoic acid (DHA) will decrease oxidative stress, white matter damage and inflammation, associated with biomarkers of efficacy and toxicity, in a model of pediatric traumatic brain injury (TBI) using male and female piglets and fluid percussion injury (FPI). Piglets will be assessed by blood, cerebrospinal fluid (CSF) and urine biomarkers on day1, 3 and 7 with brain histology on day 7



Opportunity Type:

Volunteer; Prepare a UROP proposal; Write an Honors Thesis or Senior Thesis; Earn independent study credit


Student Role:

Piglet husbandry, sample collection, bench procedures


Student Benefits:

hands-on translational science skills and experience, sub-project suitable for presentation, learn animal model and bench science relevant to medicine


Project Duration:

two years : piglets sept 2020- end of May 2021, bench work until May 2022, avg 10hr/wk but vary (piglet work, intense for 1 week, mod week2 then 0)


Minimum Requirements:

take iacuc training, willing to work with piglets, willingness to learn, reliable and professional