Platelets are small white blood cells that help prevent excessive bleeding. To stop bleeding, platelets activate, stick to damaged blood vessels and aggregate to form a clot. On the flip side, platelets also can promote dangerous clot formation such as in heart attacks and strokes. Several genes have been associated with clotting. We are using CRISPR/CAS9 gene editing in human megakaryocytes (the cells that make platelets) grown in a dish or in mice to test the role of these genes in platelet function.
Research Assistant Professor
Volunteer; This is a work-study research position; Prepare a UROP proposal; Write an Honors Thesis or Senior Thesis
The student may help with blood cell isolation, human cell culture, perform CRISPR/CAS9 transfections, polymerase Chain Reaction (PCR), microscopy, and mouse experiments.
Student will learn to design experiments and perform laboratory procedures and techniques. Students will have the opportunity to present their results in papers and posters.
8+ hours per week for > 1 year.
Must be able to work two or more 4 hour blocks per week, 2 consecutive days preferred. Some chemistry and math skills required (dilutions, calculating molarity, percentages).